Immunosorba® adsorber selectively removes type IgG antibodies from plasma by immunoadsorption.
Immunosorba® contains protein A as ligand. Found on the cell wall of bacteria, the protein has a strong binding affinity, especially for subclass 1, 2 and 4 IgG antibodies.
Protein A also binds with lower affinity to IgG subclass 3 as well as to IgM and IgA antibodies.
Given the selectivity of Protein A, other plasma proteins such as albumin are scarcely removed at all (see chart).
Alternate use of two adsorbers for the duration of each treatment session enables the removal of as many antibodies as possible. While one adsorbs, the other adsorber is regenerated.
The adsorbers can be regenerated as often as necessary during treatment.
The dosage of the immunoadsorption can be specifically adjusted to the plasma volume of each individual patient.
As a rule, 1.5 to 2.5 times the plasma volume of the patient is treated.
After treatment, they are conserved and can be reused for the same patient as often as required.
The high selectivity of Immunosorba® adsorber facilitates therapy schemes involving more than one treatment on each consecutive day.
In the case of other extracorporeal procedures, such as plasma exchange, this is not possible.