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Immunosorba®

Selective IgG adsorber for immunoadsorption using protein A

Immunosorba® adsorber selectively removes type IgG antibodies from plasma by immunoadsorption.

Immunosorba® contains protein A as ligand. Found on the cell wall of bacteria, the protein has a strong binding affinity, especially for subclass 1, 2 and 4 IgG antibodies.

Protein A also binds with lower affinity to IgG subclass 3 as well as to IgM and IgA antibodies.

Given the selectivity of Protein A, other plasma proteins such as albumin are scarcely removed at all (see chart). 

Immunosorba for immunoadsorptionImmunosorba®

Two adsobers treat a high plasma volume

Alternate use of two adsorbers for the duration of each treatment session enables the removal of as many antibodies as possible. While one adsorbs, the other adsorber is regenerated.

The adsorbers can be regenerated as often as necessary during treatment.

The dosage of the immunoadsorption can be specifically adjusted to the plasma volume of each individual patient.

As a rule, 1.5 to 2.5 times the plasma volume of the patient is treated. 

After treatment, they are conserved and can be reused for the same patient as often as required.

Treatment results with ImmunosorbaAverage IgG, IgM, IgA and albumin reduction after treatment of > 7.5 l plasma (n =22) with Immunosorba® (Chart modified from1)

Immunoadsorption with Immunosorba®

The high selectivity of Immunosorba® adsorber facilitates therapy schemes involving more than one treatment on each consecutive day.

In the case of other extracorporeal procedures, such as plasma exchange, this is not possible.

Immunoadsorption process with ImmunosorbaThe Immunosorba® adsorbers use protein A for the group-specific binding of antibodies.

Benefits of treatment with Immunosorba®

  • Dual absorption system with continuous regeneration during an ongoing treatment
  • Can be reused for the same patient
  • Very few treatment-related adverse effects2
  • Removes immunoglobulins and immunocomplexes selectively and efficiently1,3
  • Reduces IgG antibodies to the desired levels by selection of the plasma volume to be treated1

Clinical setup

  • A clinical setup requires the Art Universal device for plasma separation and the ADAsorb® machine for the column management.
  • As an alternative to the ART Universal device, a centrifuge could be used to obtain plasma
Immunosorba clinical setupImmunosorba® clinical setup

References

  1. Gjörstrup P, Watt R M: Therapeutic Protein A Immunoadsorption. A Review. Transfusion Science 1990; 11: 281-302.
  2. Doesch et al, Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy. Journal of Clinical Apheresis 2010; 25(6): 315-22.
  3. Belàk et al, Technical and Clinical Experience with Protein A Immunoadsorption Columns. Transfusion Science 1994; 15: 419-22.

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