Effective lipoprotein filtration with MONET®

MONET® stands for Membrane Filtration Optimized Novel Extracorporeal Treatment.

Lipoprotein filtration with MONET® is used to reduce high molecular weight molecules such as:

  • High molcular weight lipoproteins — specifically LDL-C and Lp(a)
  • High molcular weight plasma proteins that are rheological relevant 

The MONET® plasma fractionator contains a Fresenius Polysulfone® membrane, enhanced for use in lipoprotein filtration.

The membrane has the same excellent biocompatibilities as other Fresenius filters and is the result of our continuous product improvement procedures.

MONET lipoprotein filtrationMONET ® lipoprotein filtration

MONET® treatment procedure

During lipoprotein filtration, venovenous or AV fistula access can be used. The procedure consists of two steps:

In step one, the plasma is separated from whole blood by plasma filtration or centrifugation.

In step two, the plasma is passed through a second filter, the MONET® plasma fractionator. MONET® retains high-molecular components, such as:

  • Low density lipoprotein (LDL)
  • Very low density lipoprotein (VLDL)
  • Lp(a)
  • Triglycerides
  • Fibrinogen
  • IgM and IgA 

Finally, the purified plasma is combined again with the whole blood and returned to the patient.

MONET plasma fractionationMONET® runs as a plasma fractionator

Benefits of treatment with MONET®

  • Effective reduction of LDL-C and Lp(a) levels1
  • Rheological benefits result from the reduction of macromolecules, fibrinogen and immunoglobulines1, 2
  • Broad range of possible indications
  • Substantiated filtration procedure

Anticoagulation can be customized according to the patient’s needs

Four different anticoagulation regimes are possible:

  • ACD-A, continuously throughout the treatment procedure
  • Heparin, continuously throughout the treatment procedure
  • ACD-A and Heparin, combined continuously throughout the treatment procedure
  • Heparin manually during the treatment procedure or as an initial patient bolus prior to treatment

Clinical setup

MONET® can be carried out with:

  • Either the haemoadsorption machine Art Universal
  • Or a blood cell separator / centrifuge (e.g. COM.TEC®)
MONET clinical setupMONET® clinical setup


  1. Julius U et al.; Therapeutic Apheresis and Dialysis Apr. 2013; 17(2): 179–84.
  2. Julius U et al.; Atherosclerosis Supplements May 2015; 18: 95–102.

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